Meeting programme

Wednesday 24 September 2025

 

09:00 - 10:00              Registration

 

10:00 - 10:15              Opening of the meeting - Introduction

 

Session I                   NHEJ molecular dynamics

                                   Chairs: Francisca Lottersberger & Ludovic Deriano

10:15 - 10:40              Jeremy Stark

                                   Genetic Regulation of Diverse Chromosomal Break Repair Outcomes

10:40 - 11:00              Jinhang Zhang

                                   PAXX acts as a molecular tether during non-homologous end joining

11:00 - 11:25              Sébastien Britton

                                   Mechanisms antagonizing Ku at DNA double-strand breaks

11:25 - 11:45              Theodore Bellon

                                   Understanding the Role of APLF in the NHEJ Pathway: Homotypic and                                                        Intramolecular Interactions Revealed by NMR

11:45 - 12:10              Shingo Fujii

                                   DNA-PKcs facilitates NHEJ in vitro

 

12:10 - 13:10              Lunch

 

13:10 - 14:10              Poster session

 

Session II                  NHEJ structure and function

                                   Chairs: Sarah Lambert & Karl-Peter Hopfner

14:10 - 14:35              Wei Yang

                                   NHEJ: The Finishing Touch of V(D)J Recombination

14:35 - 14:55              Shan Zha

                                   The Tale of Two Tails – the role of Ku70 and Ku80 C-terminal domains

14:55 - 15:20              Marc Delarue

                                   Insights into the X-family DNA Polymerases in NHEJ and structural studies of the                                        short-range complex in yeast

 

15:20 - 15:50              Coffee break

 

15:50 - 16:15              Chloe Hall

                                   Cryo-EM structures of NHEJ assemblies bound to nucleosomes

16:15 - 16:35              Andrea Kaminsky 

                                   Structural basis of strand-specific repair by Family X polymerases in                                                             nonhomologous end-joining

16:35 - 17:00              Sylvie Doublié

                                   Insights into the Architecture and Activity of Human DNA Polymerase Theta

 

19:00 - 23:00              Dinner

 

Thursday 25 September 2025

 

Session III                 NHEJ and programmed rearrangements

                                   Chairs: Wei Yang & Mauro Modesti

09:30 - 09:55              Jean-Pierre de Villartay

                                   ”2 ou 3 choses que je sais d’elle”: The V(D)J Recombination

09:55 - 10:15              Richard Frock

                                   Parallel DNA Joint Capture Identifies Recombination and End Stability Regulators

10:15 - 10:35              Agnieszka Lukaszewicz

                                   De novo translocations from end joining of meiotic DSBs in mice

10:35 - 11:00              Ludovic Deriano

                                   Polymerase theta repairs persistent G1-induced DNA breaks in S-phase during                                           class switch recombination

 

11:00 - 11:30              Coffee break

 

11:30 - 11:55              Dipanjan Chowdhury

                                   BRCA1-dependent ubiquitination of Shieldin governs DSB repair pathway choice at                                     replication forks and determines PARP inhibitor response

11:55 - 12:15              Julien Bischerour

                                   A hybrid complex composed of repair proteins assembles for precise DNA                                                    elimination in Paramecium tetraurelia

12:15 - 12:35              Luciana Cacciottola

                                   Follicle growth triggers DNA repair pathways transition from HR to NHEJ                                                     following irradiation

 

12:35 - 13:10              Lunch

 

13:10 - 14:10              Poster session

 

Session IV                 Regulation of DSB repair 1

                                   Chairs: Karine Dubrana & Jeremy Stark

14:10 - 14:35              Gaëlle Legube

                                   Transcriptional repression accounts for RNA:DNA hybrid accumulation at DNA                                            Double Strand breaks

14:35 - 14:55              Adam Luthman

                                   RNA incorporation is essential for efficient and accurate nonhomologous end joining

14:55 - 15:20              Sarah Lambert

                                   Molecular determinants of the replication-associated functions of the NHEJ KU                                            factor

 

15:20 - 15:50              Coffee break

 

                                   Alternative roles for NHEJ factors

15:50 - 16:15              Katherine Meek

                                   Ablations of the two subunits of the DNA-dependent protein kinase have distinct                                           cellular impacts

16:15 - 16:35              Oscar Llorca

                                   Structural basis of Ku70/Ku80 targeting by Vaccinia Virus

16:35 - 17:00              Titia de Lange

                                   Human Ku70/80 plays an essential role in ribosome biogenesis

 

19:00 - 23:00              Dinner

 

Friday 26 September 2025

 

Session V                  NHEJ, MRN and telomeres

                                   Chairs: Titia de Lange and Sébastien Britton

09:30 - 09:55              Tanya Paull

                                   NHEJ intersections with homologous recombination factors

09:55 - 10:15              Stéphane Coulon

                                   Telomeres protection by the shelterin in fission yeast

10:15 - 10:35              Joey Dufourd

                                   TELS1 stabilizes t-loops independently of TRF2 in ESCs and MEFs

10:35 - 11:00              Karl-Peter Hopfner

                                   Structural Basis for DNA Break Sensing by Human MRE11-RAD50-NBS1 and its                                        Regulation by Telomeric Factor TRF2

 

11:00 - 11:30              Coffee break

 

11:30 - 11:50              Shawn Ahmed

                                   Rewriting the sequence of telomeric DNA

11:50 - 12:10              Sara Castelli

                                   Unravelling a Mechanism of NHEJ Inhibition at Telomeres

12:10 - 12:35              Francisca Lottersberger

                                   Balancing DNA-PK Activation and Inhibition at Telomeres

 

12:35 - 13:30              Lunch

 

13:30 - 14:30              Poster session

 

Session VI                 Regulation of DSB repair 2

                                   Chairs: Katherine Meek & Marc Delarue

14:30 - 14:50              Julien Karazi

                                   Understanding the Ku-WRN interplay at stalled replication fork as a novel                                                    therapeutic target in precision oncology

14:50 - 15:10              Chloe Lescale

                                   CST is epistatic with Shieldin to limit DNA double-strand break end resection and                                        promote repair during Igh class switch recombination

15:10 - 15:35              Karine Dubrana

                                   MRX-dependent tethering of DNA double-strand breaks to the nuclear pore complex                                    regulates NHEJ in G1

 

15:35 - 16:00              Meeting discussion and concluding remarks

 

16:00                          End of the meeting